Slow Axoplasmic Transport
نویسندگان
چکیده
منابع مشابه
Slow axoplasmic transport under scrutiny.
The origin of axoplasmic proteins is central for the biology of axons. For over fifty years axons have been considered unable to synthesize proteins and that cell bodies supply them with proteins by a slow transport mechanism. To allow for prolonged transport times, proteins were assumed to be stable, i.e., not degraded in axons. These are now textbook notions that configure the slow transport ...
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Axoplasmic proteins in the crayfish nerve cord were labeled by the incorporation of high specific activity (3)H-leucine that was injected into one of the abdominal ganglia. The labeled proteins moved caudad as a sharply defined peak at 1.1 mm/day. The level of radioactivity in the cord decreased slowly as the peak approached the tail. From the sharpness of the peak and the low decrement of labe...
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The rate and extent of axoplasmic transport of the brain-specific soluble protein (14-3-2 protein) has been investigated in the avian visual system. 1-day-old chicks were injected monocularly with tritiated proline, Incorporation of the isotope into the 14-3-2 protein synthesized within the retina of the injected eye, as well as the appearance of the labeled protein in the optic lobes was deter...
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Tubulin proteins in mouse retinal ganglion cell (RGC) neurons were analyzed to determine whether they undergo posttranslational processing during axoplasmic transport. ~and /~-tubulin comprised heterogeneous proteins in the primary optic pathway (optic nerve and optic tract) when examined by two-dimensional (2D) PAGE. In addition, however, ~tubulin exhibited regional heterogeneity when consecut...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 1977
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.53.252